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    SubjectsPathologyConfined Placental Mosaicism - CVS vs Fetal Karyotype Discordance
    Para-clinicalPathology

    Confined Placental Mosaicism - CVS vs Fetal Karyotype Discordance

    1 MCQs in Pathology for NEET PG

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    A 34-year-old pregnant woman at 12 weeks gestation undergoes chorionic villus sampling (CVS) after abnormal first-trimester screening. CVS shows trisomy 16 in 75% of cultured villus cells, but confirmatory amniocentesis at 16 weeks reveals a normal 46,XX karyotype in all amniocytes. Postnatal testing confirms the infant has a normal karyotype in peripheral blood and skin fibroblasts, but the pregnancy was complicated by severe intrauterine growth restriction with delivery at 34 weeks. The condition illustrated by structure **A** in the diagram represents which of the following pathophysiological mechanisms?

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