2 MCQs in Pathology for NEET PG
A 65-year-old man presents with rapidly enlarging cervical lymphadenopathy, fever, and night sweats. Excisional lymph node biopsy shows sheets of large atypical cells with diffuse architectural effacement, vesicular nuclei, and prominent nucleoli. Immunohistochemistry reveals the immunoprofile marked **D** in the diagram. Which of the following statements best reflects the diagnostic and therapeutic significance of this immunoprofile in Diffuse Large B-Cell Lymphoma?
A 64-year-old man presents with 6 weeks of progressive right neck swelling, drenching night sweats, and 5 kg weight loss. Excisional biopsy of the cervical lymph node shows complete effacement of nodal architecture by sheets of large lymphoid cells with vesicular nuclei and prominent nucleoli. Tingible-body macrophages are scattered throughout, producing a characteristic starry-sky pattern. The structure marked **B** in the diagram shows CD20 strongly and diffusely positive cells with a Ki-67 proliferation index of 70%. FISH studies reveal MYC translocation WITHOUT BCL2 rearrangement. Which of the following is the most appropriate first-line therapeutic approach for this patient?
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