1 MCQs in Pathology for NEET PG
A 62-year-old man presents with rapidly enlarging left cervical lymphadenopathy, B-symptoms (fever, night sweats, weight loss), hepatosplenomegaly, markedly elevated serum LDH (1240 U/L), and corrected calcium of 11.6 mg/dL. Excisional lymph node biopsy shows sheets of large atypical lymphoid cells with 95% KI-67 proliferation index and CD20+, CD10+, BCL6+ immunophenotype. FISH analysis is performed using break-apart probes. The structure marked **A** in the diagram (MYC break-apart signal at 8q24 showing split red/green signal) is identified as rearranged. Which of the following best describes the prognostic and therapeutic significance of this finding in the context of this patient's disease?
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