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    SubjectsPathologyFISH — Chronic Myeloid Leukemia BCR-ABL Fusion Confirmation
    Para-clinicalPathology

    FISH — Chronic Myeloid Leukemia BCR-ABL Fusion Confirmation

    1 MCQs in Pathology for NEET PG

    1 Medium
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    A 62-year-old Indian man presents with fatigue and left upper quadrant fullness. CBC shows WBC 180,000/μL with left-shifted myeloid series and basophilia. Bone marrow aspirate is hypercellular with M:E ratio 15:1. FISH analysis of bone marrow interphase nuclei is performed, and the result shown in the diagram displays two fusion signals (marked **A**). Which of the following best explains the pathogenic mechanism of the clonal myeloproliferative neoplasm in this patient?

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