1 MCQs in Pathology for NEET PG
A 52-year-old man presents with a 4-month history of progressive fatigue, easy bruising, and recurrent sinopulmonary infections. Examination reveals massive isolated splenomegaly without lymphadenopathy. Complete blood count shows pancytopenia with monocytopenia (0.1 × 10⁹/L). Peripheral blood smear demonstrates characteristic hairy cells with eccentric nuclei and cytoplasmic projections. Bone marrow trephine biopsy shows a diffuse interstitial infiltrate with a "fried-egg" appearance. Immunohistochemistry is positive for CD20, CD11c, CD25, CD103, ANNEXIN A1, and TRAP. Targeted sequencing reveals the mutation marked **A** in the diagram. Which of the following best describes the significance of this mutation in this patient's diagnosis?
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