1 MCQs in Pathology for NEET PG
A 28-year-old man from rural Nigeria presents with a history of recurrent malaria episodes despite living in a malaria-endemic region. Genetic testing reveals he is heterozygous for the sickle cell mutation (HbAS). The diagram shows four mechanisms by which genetic polymorphisms persist in populations. The mechanism marked **A** explains why the sickle cell allele remains at high frequency (5–15%) in sub-Saharan Africa despite causing severe disease in homozygotes. Which of the following best describes the population-genetic principle represented by structure **A**?
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