1 MCQs in Pathology for NEET PG
A 38-year-old Indian woman presents to the emergency department with severe epistaxis, gum bleeding, and petechiae. Peripheral blood smear shows hypergranular promyelocytes with bundles of Auer rods. Coagulation studies reveal prolonged PT/aPTT, low fibrinogen (80 mg/dL), and elevated D-dimer. FISH analysis of bone marrow is performed. The fusion signal marked **A** in the diagram is detected in >98% of blast cells. Which of the following best describes the molecular mechanism by which this fusion signal drives the pathogenesis of this leukemia?
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