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    SubjectsPathologyKaryotype — Burkitt Lymphoma t(8;14)
    Para-clinicalPathology

    Karyotype — Burkitt Lymphoma t(8;14)

    1 MCQs in Pathology for NEET PG

    1 Hard
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    Sample Questions

    hard

    A 7-year-old boy from rural India presents with a rapidly enlarging abdominal mass and acute intestinal obstruction. Imaging shows an ileocecal mass. Biopsy reveals a high-grade lymphoma with starry-sky appearance and Ki-67 index of ~100%. Cytogenetic analysis shows t(8;14)(q24;q32). The structure marked **B** in the karyotype diagram represents the molecular consequence of this translocation. Which of the following best explains the pathogenic mechanism of the structure marked **B**?

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