Karyotype — Burkitt Lymphoma t(8;14) MYC-IGH FISH

A 6-year-old boy from rural India presents with a rapidly enlarging left-sided jaw mass and facial swelling over 3 weeks. Serum LDH is markedly elevated (2200 U/L). A biopsy shows medium-sized monomorphic blue cells with a starry-sky pattern and Ki-67 >95%. FISH analysis is performed on the specimen. The signal marked **A** in the diagram represents the hallmark finding in this patient's diagnosis. Which of the following best describes the molecular basis of this translocation and its pathogenic consequence?