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    SubjectsPathologyKaryotype — Philadelphia Chromosome t(9;22) CML
    Para-clinicalPathology

    Karyotype — Philadelphia Chromosome t(9;22) CML

    1 MCQs in Pathology for NEET PG

    1 Hard
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    Sample Questions

    hard

    A 62-year-old Indian man presents with fatigue, early satiety, and left upper quadrant pain. CBC shows WBC 185,000/μL with left-shifted granulocytes (myelocytes > metamyelocytes > bands > segmented), basophilia, and thrombocytosis. Bone marrow is hypercellular. The karyotype notation marked **D** in the diagram reads 46,XY,t(9;22)(q34;q11). Which of the following best describes the molecular consequence of the translocation event denoted by this karyotype notation?

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