Lung Cancer — Non-Small Cell

A 58-year-old woman with advanced adenocarcinoma of the lung (stage IV, brain metastases) is found to have an EGFR exon 19 deletion mutation on molecular testing. She has never smoked. What is the drug of choice for first-line treatment?

A 58-year-old male smoker (40 pack-years) presents with persistent cough and haemoptysis for 3 weeks. Chest X-ray shows a 4 cm peripheral nodule in the right lower lobe with irregular borders. CT chest reveals no mediastinal lymphadenopathy. Bronchoscopy with biopsy shows malignant cells arranged in nests with prominent desmoplastic stromal reaction and keratinization. What is the most likely histological type of lung cancer?

Squamous cell carcinoma of the lung most commonly arises from which anatomical location within the bronchial tree?

A 62-year-old woman with no smoking history presents with progressive dyspnoea and chest pain. Chest X-ray shows a 5 cm mass in the left lower lobe with pleural involvement. CT chest confirms T4N2M0 disease. Bronchoscopy shows no endobronchial lesion. Biopsy reveals a well-differentiated tumour with mucin-producing glandular structures and absence of keratinization. Immunohistochemistry is positive for TTF-1 and CK7. What is the most likely histological type and what is the significance of TTF-1 positivity?

A 58-year-old male smoker presents with a 3-month history of cough and hemoptysis. CT chest shows a 4 cm peripheral mass in the right lower lobe. Bronchoscopy and biopsy confirm adenocarcinoma of the lung. Staging workup reveals stage IIIA disease (T3N2M0) with no distant metastases. The patient is deemed suitable for concurrent chemoradiotherapy. Which of the following is the drug of choice for chemotherapy in this regimen?