Lung Cancer — Small Cell

Regarding small cell lung cancer (SCLC), all of the following statements are correct EXCEPT:

A 58-year-old male smoker presents with a 3-month history of cough, chest pain, and weight loss. Imaging reveals a central lung mass with mediastinal lymphadenopathy. Bronchoscopic biopsy confirms small cell lung cancer (SCLC) with extensive stage disease. Which is the drug of choice for first-line chemotherapy in this patient?

A 58-year-old male with a 40 pack-year smoking history is found to have small cell lung cancer on bronchoscopic biopsy. Which is the most common site of distant metastasis in SCLC at the time of diagnosis?

A 62-year-old woman with extensive-stage small cell lung cancer has completed 4 cycles of cisplatin + etoposide with a partial response. She is now in remission and clinically stable. Which agent is the drug of choice for maintenance therapy to prolong overall survival?

A 62-year-old male smoker presents with central chest pain, cough, and hemoptysis. Chest X-ray shows a hilar mass with mediastinal widening. Bronchoscopic biopsy reveals small round cells with scant cytoplasm, fine chromatin, and numerous mitoses. Immunohistochemistry is positive for synaptophysin and chromogranin A. All of the following are true regarding this patient's condition EXCEPT: