Neuroblastoma — Homer-Wright Rosettes

A 2-year-old boy presents with an abdominal mass that crosses the midline on imaging. Histopathology shows small round blue cells arranged around central neuropil, as marked by **A** in the diagram. Urinary metabolites including homovanillic acid (HVA) and vanillylmandelic acid (VMA) are elevated. Which of the following best describes the origin of this tumor?

A 2-year-old boy presents with an abdominal mass discovered on routine examination. Imaging confirms a left adrenal tumor with metastases to liver and bone. Histopathology reveals small round blue cells with the characteristic feature marked **B** in the diagram — cells arranged around a central fibrillary neuropil without true lumen formation. Urinary VMA and HVA are markedly elevated. Which of the following best describes the histological significance of the structure marked **B** in establishing the diagnosis of neuroblastoma?