4 MCQs in Pathology for NEET PG
A 62-year-old woman from Delhi presents with a 2-year progressive history of memory loss, confusion, and visual hallucinations. She has myoclonus and periodic sharp wave complexes on EEG. CSF 14-3-3 protein is markedly elevated. Brain MRI shows cortical ribboning and basal ganglia hyperintensity on DWI/FLAIR sequences. What is the primary pathological mechanism underlying this condition?
A 58-year-old man from rural Maharashtra presents with a 3-year history of progressive tremor at rest, rigidity, and bradykinesia. He reports difficulty initiating gait and frequent falls. Examination reveals a stooped posture, masked facies, and a pill-rolling tremor. MRI brain shows no structural lesion. What is the most likely pathological finding in the substantia nigra?
Which pathological hallmark protein is characteristically found in the substantia nigra and locus coeruleus in Parkinson's disease?
In Huntington's disease, the mutated gene encodes a protein with an abnormal expansion of which amino acid repeat?
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