Peptic Ulcer Disease

A 38-year-old woman from Mumbai with a 6-week history of recurrent epigastric pain is found on upper GI endoscopy to have a 2 cm gastric ulcer on the lesser curvature. She denies NSAID use and H. pylori serology is negative. Which investigation is most appropriate to exclude a malignant lesion in this gastric ulcer?

A 48-year-old woman with a gastric ulcer refractory to 8 weeks of omeprazole therapy is found to be H. pylori-negative on repeat endoscopy with biopsy. NSAIDs were discontinued 2 months ago. What is the drug of choice for long-term management of this refractory ulcer?

A 52-year-old man with a 10-year history of duodenal ulcer disease presents with epigastric pain and heartburn. Upper endoscopy confirms an active duodenal ulcer. He is H. pylori-positive on rapid urease test. What is the drug of choice for initial eradication therapy in this patient?

A 42-year-old man from Delhi presents with a 3-month history of epigastric pain relieved by food and antacids. Upper GI endoscopy reveals a 1.5 cm ulcer on the anterior wall of the first part of the duodenum with clean base. Which investigation is most appropriate to confirm the aetiology of this peptic ulcer?

A 52-year-old man from Delhi presents with chronic epigastric pain and a history of NSAID use for arthritis. Endoscopy reveals a gastric ulcer. Which is the most common site of peptic ulcer disease in the stomach?