1 MCQs in Pathology for NEET PG
A 58-year-old male smoker presents with incidental discovery of a 6 cm left renal mass on contrast-enhanced CT. Histopathology shows nests of polygonal cells with abundant **A** (clear cytoplasm containing glycogen and lipid), distinct cell borders, and delicate arborizing sinusoidal vasculature. Immunohistochemistry is positive for PAX8, CD10, and CA9, and negative for CK7. Which of the following molecular events is the CARDINAL pathogenic mechanism underlying this tumor?
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