1 MCQs in Pathology for NEET PG
A 58-year-old sandblaster with 30 years of occupational exposure to crystalline silica presents with progressive dyspnea, dry cough, and hemoptysis. Chest radiograph shows bilateral upper lobe small round nodules and hilar lymphadenopathy with eggshell calcification. The structure marked **A** in the diagram represents the firm gray-black nodules in the upper lobe parenchyma. Microscopic examination of these nodules reveals concentric whorled hyalinized collagen with weakly birefringent silica particles and peripheral dust-laden macrophages. Which of the following pathogenic mechanisms is primarily responsible for the formation of these silicotic nodules?
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