SLE and Autoimmune Disorders

A 32-year-old woman is diagnosed with systemic lupus erythematosus based on clinical and serological criteria. Which of the following is the most common autoantibody found in SLE?

A 32-year-old woman from Mumbai with a 2-year history of SLE (ANA positive, anti-dsDNA positive, anti-Smith positive) presents with acute onset dyspnea, pleuritic chest pain, and a new pericardial friction rub on auscultation. Chest X-ray shows bilateral pleural effusions. Echocardiography reveals a small pericardial effusion without tamponade. Complete blood count shows hemoglobin 9.2 g/dL, WBC 3,200/μL, and platelets 95,000/μL. Which of the following pathologic mechanisms best explains the pleural and pericardial involvement in this patient?

A 28-year-old woman with newly diagnosed SLE presents with mild arthralgia, photosensitive rash, and positive ANA. She has normal renal function and no CNS involvement. What is the drug of choice for initial management?

A 28-year-old woman with systemic lupus erythematosus presents with progressive renal dysfunction and proteinuria. Kidney biopsy is performed. Which of the following is the most common histopathological pattern of lupus nephritis?

In systemic lupus erythematosus, which complement component deficiency is most strongly associated with increased risk of SLE development and is thought to impair clearance of immune complexes and apoptotic cells?