1 MCQs in Pathology for NEET PG
A 14-year-old boy presents with a 2-week history of progressive dyspnea, cough, and chest pain. Imaging reveals a large anterior mediastinal mass. Bone marrow examination shows 45% blasts that are TdT+ and CD3+ (cytoplasmic). Cytogenetics and molecular testing identify the translocation marked **A** in the diagram — t(7;9)(q34;q34.3) — which juxtaposes the TCR-beta enhancer to a truncated NOTCH1. Which of the following best describes the pathogenic consequence of this translocation?
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