1 MCQs in Pathology for NEET PG
A 52-year-old Caucasian man presents with a 3-month history of chronic sinusitis with bloody nasal discharge, progressive nasal bridge collapse (saddle-nose deformity), and recent hemoptysis with bilateral pulmonary nodules on chest CT. Serum creatinine is rising (2.8 mg/dL), and urinalysis shows proteinuria with RBC casts. A nasal biopsy is performed. Histopathology reveals geographic necrosis in the center with **surrounding granulomatous inflammation (marked B)**, along with necrotizing small-vessel vasculitis. C-ANCA/anti-PR3 serology is positive. Which of the following best explains the pathologic significance of the structure marked **B** in establishing the diagnosis of GPA?
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